Dissemination of an antibiotic resistance plasmid in hospital patient flora

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Dissemination of an antibiotic resistance plasmid in hospital patient flora.

The 2'' aminoglycoside nucleotidyltransferase, AAD (2''), which adenylates gentamicin, tobramycin, and kanamycin, became prevalent over several months in multiple strains and species of Enterobacteriaceae isolated at one hospital. Eight plasmids with the gene for this enzyme purified from different strains and species isolated at different times had similar EcoRI digestion fragments, indicating...

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Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum βlactamases (ESBL) are bacterial enzymes that degrade β-lactam antibiotics and thus make the bacteria resistant to β-lactam antibiotics. ESBL-producing Enterobacteriaceae (EPE) is an increasing problem constituting a burden o...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1980

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.17.4.537